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Axel H Schönthal Selected Research

NEO212

2/2024Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide.
12/2022NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity.
7/2021Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia.
1/2020Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas.
1/2020Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice.
1/2019Cytotoxic impact of a perillyl alcohol-temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro.
1/2018NEO212 Inhibits Migration and Invasion of Glioma Stem Cells.
2/2016A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells.
8/2015Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo.
3/2015A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
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Axel H Schönthal Research Topics

Disease

74Neoplasms (Cancer)
02/2024 - 05/2002
29Glioma (Gliomas)
01/2021 - 05/2002
22Glioblastoma (Glioblastoma Multiforme)
12/2023 - 01/2004
11Brain Neoplasms (Brain Tumor)
12/2023 - 08/2008
7Breast Neoplasms (Breast Cancer)
12/2021 - 10/2006
6Hypoxia (Hypoxemia)
01/2021 - 09/2007
5Multiple Myeloma
03/2019 - 12/2005
5Carcinoma (Carcinomatosis)
06/2012 - 05/2003
4Melanoma (Melanoma, Malignant)
01/2023 - 03/2015
4Carcinogenesis
01/2013 - 05/2003
3Neoplasm Metastasis (Metastasis)
10/2021 - 05/2014
3Hypoglycemia (Reactive Hypoglycemia)
03/2013 - 01/2012
3Colonic Neoplasms (Colon Cancer)
02/2008 - 04/2004
2Nasopharyngeal Carcinoma
02/2024 - 08/2015
2Lymphoma (Lymphomas)
12/2023 - 02/2010
2Cicatrix (Scar)
01/2023 - 01/2020
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2022 - 07/2021
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2007 - 11/2005
2Lung Neoplasms (Lung Cancer)
12/2006 - 11/2005
1Contusions
01/2023
1Leukopenia
12/2022

Drug/Important Bio-Agent (IBA)

28perillyl alcoholIBA
02/2024 - 11/2012
25Temozolomide (Temodar)FDA LinkGeneric
02/2024 - 04/2006
21Celecoxib (Celebrex)FDA Link
12/2012 - 01/2004
12Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2006
11NEO212IBA
02/2024 - 08/2014
10Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
12/2012 - 01/2004
9Cyclooxygenase 2 (Cyclooxygenase-2)IBA
07/2010 - 05/2005
8Endoplasmic Reticulum Chaperone BiPIBA
03/2013 - 04/2007
7DNA (Deoxyribonucleic Acid)IBA
12/2022 - 03/2011
72,5-dimethylcelecoxibIBA
12/2012 - 04/2006
6MethyltransferasesIBA
12/2023 - 08/2014
5Chloroquine (Aralen)FDA LinkGeneric
12/2023 - 12/2012
5Alkylating AgentsIBA
12/2022 - 03/2011
5Antineoplastic Agents (Antineoplastics)IBA
11/2020 - 07/2005
5Bortezomib (Velcade)FDA Link
03/2019 - 02/2008
5Irinotecan (Camptosar)FDA LinkGeneric
03/2015 - 05/2006
5Nelfinavir (Viracept)FDA Link
12/2012 - 11/2007
5Proteasome Endopeptidase Complex (Proteasome)IBA
09/2011 - 12/2006
5SurvivinIBA
09/2011 - 05/2006
5Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
07/2010 - 01/2004
4Small Interfering RNA (siRNA)IBA
02/2008 - 09/2006
3RolipramIBA
12/2023 - 05/2002
3EnzymesIBA
12/2022 - 11/2005
3Monoterpenes (Monoterpenoids)IBA
08/2022 - 11/2012
3Bevacizumab (Avastin)FDA Link
01/2022 - 03/2015
3Adenosine Triphosphate (ATP)IBA
01/2022 - 10/2007
3Trastuzumab (Herceptin)FDA Link
12/2021 - 09/2009
3IntegrinsIBA
11/2020 - 07/2005
3DisintegrinsIBA
11/2020 - 07/2005
3Snake Venoms (Snake Venom)IBA
11/2020 - 07/2005
3Glucose (Dextrose)FDA LinkGeneric
01/2020 - 09/2007
3Proteasome InhibitorsIBA
03/2019 - 06/2009
3Hormones (Hormone)IBA
12/2012 - 05/2002
3Drug CombinationsIBA
12/2012 - 02/2008
3Apoptosis Regulatory ProteinsIBA
09/2011 - 05/2006
3epigallocatechin gallate (epigallocatechin-3-gallate)IBA
03/2011 - 10/2007
3Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
07/2010 - 01/2004
3Caspase 7IBA
06/2009 - 10/2007
3LigandsIBA
11/2007 - 09/2006
2Transcription Factors (Transcription Factor)IBA
12/2023 - 05/2003
2O-(6)-methylguanineIBA
12/2022 - 01/2020
2Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2022 - 12/2003
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2019 - 03/2015
2bromopyruvateIBA
11/2018 - 01/2017
2GuanineIBA
09/2018 - 08/2014
2Antimalarials (Antimalarial Agents)IBA
03/2015 - 12/2012
2quinolineIBA
03/2015 - 12/2012
2Mefloquine (Lariam)FDA LinkGeneric
03/2015 - 12/2012
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
03/2015 - 03/2010
2TunicamycinIBA
01/2013 - 01/2012
2ThapsigarginIBA
01/2013 - 01/2012
2HIV Protease InhibitorsIBA
12/2012 - 09/2009
2Cytotoxins (Cytolysins)IBA
11/2012 - 03/2011
2CalciumIBA
01/2012 - 04/2007
2TeaIBA
03/2011 - 06/2009
2Topoisomerase I InhibitorsIBA
03/2011 - 03/2007
2CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
11/2007 - 12/2006
2UbiquitinIBA
11/2007 - 12/2006
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2007 - 12/2006
2TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
11/2007 - 12/2006
2contortrostatinIBA
09/2005 - 07/2005
2Cyclin-Dependent Kinases (cdk Proteins)IBA
01/2004 - 05/2002
2Cyclin BIBA
01/2004 - 05/2002
2ProgesteroneFDA LinkGeneric
12/2003 - 05/2002
1Antiviral Agents (Antivirals)IBA
02/2024
1Ganciclovir (Cytovene)FDA LinkGeneric
02/2024
1Chimeric Antigen ReceptorsIBA
12/2023
1bafilomycin A1IBA
12/2023
1Sirolimus (Rapamycin)FDA Link
12/2023
1Phosphotransferases (Kinase)IBA
12/2023
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
12/2023
1Lysosomal-Associated Membrane Protein 1IBA
12/2023
1AntibodiesIBA
01/2023
1A-Form DNA (A-DNA)IBA
12/2022

Therapy/Procedure

34Therapeutics
12/2023 - 09/2005
12Drug Therapy (Chemotherapy)
01/2020 - 09/2005
4Intranasal Administration
08/2022 - 11/2012
2Radiotherapy
01/2020 - 12/2014
2Chemoprevention
01/2015 - 12/2006